Varenicline is a prescription only oral medicine used to help people stop smoking. It works on nicotine receptors in the brain, reducing cravings and withdrawal while also blunting the rewarding effect if a person does smoke.
In Australia, varenicline is PBS listed for eligible patients and is typically taken over a twelve week course, starting one to two weeks before the planned quit date. A doctor reviews mental health history and other medicines before prescribing, and support during the course improves success.